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I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y.

机译：甲型H1N1流感病毒中的I223R突变pdm09神经氨酸酶可降低对奥司他韦和扎那米韦的敏感性，并增强对H275Y的耐药性。

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Jérome LeGoff; Dominique Rousset; Georges Abou-Jaoudé; Anne Scemla; Patricia Ribaud; Séverine Mercier-Delarue; Valérie Caro; Vincent Enouf; François Simon; Jean-Michel Molina; Sylvie van der Werf;
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1. Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses [J] . Jeff Butler, Kathryn A. Hooper, Stephen Petrie, PLoS Pathogens . 2014,第4期

机译：估计最近耐奥司他韦的A（H1N1）pdm09流感病毒中允许的神经氨酸酶突变所带来的健身优势
2. In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir [J] . Jennifer L. McKimm-Breschkin12* Christina Rootes2 Peter G. Mohr2 Susan Barrett12 and Victor A. Streltsov1 Journal of Antimicrobial Chemotherapy . 2012,第8期

机译：大流行H1N1 / 09病毒的体外传代选择了具有神经氨酸酶突变的病毒，这些病毒赋予了对oseltamivir和peramivir的高水平耐药性，但对zanamivir没有
3. In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir [J] . Mckimm-BreschkinJ.L., RootesC., MohrP.G., The Journal of Antimicrobial Chemotherapy . 2012,第8期

机译：大流行H1N1 / 09病毒的体外传代选择了具有神经氨酸酶突变的病毒，这些病毒赋予了对oseltamivir和peramivir的高水平抗药性，但对zanamivir没有抗药性
4. Simulated Docking of Oseltamivir with the 1918 Pandemic Strain Influenza A/H1N1 "Zanamivir-Conformed" Neuraminidase Active Site [C] . Jack K. Homer International Conference on Genetic and Evolutionary Methods . 2011

机译：用1918大流行菌甲型流感A / H1N1“Zanamivir-符合”神经氨酸活性位点模拟对接
5. I223R Mutation in Influenza A(H1N1)pdm09 Neuraminidase Confers Reduced Susceptibility to Oseltamivir and Zanamivir and Enhanced Resistance with H275Y [O] . Jérome LeGoff, Dominique Rousset, Georges Abou-Jaoudé, -1

机译：I223R突变流感a（H1N1）pdm09神经氨酸酶赋予敏感性降低到奥司他韦和扎那米韦和与H275Y抗性提高
6. In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir [O] . J. L. McKimm-Breschkin, C. Rootes, P. G. Mohr, 2012

机译：大流行H1N1 / 09病毒的体外传递用于赋予Oseltamivir和Peramivir的高水位抗性的神经氨酸酶突变的病毒，但不是Zanamivir

I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y.

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